The Malaysian Insider :: Features
The Malaysian Insider :: Features |
| Swiss researchers take a step to unlocking mystery of ageing Posted: 23 May 2013 09:09 AM PDT
"They were not only living longer, but were also more fit," said Johan Auwerx ion a video released by the Ecole Polytechnique Federale de Lausanne (EPFL), a cutting-edge Swiss research institute. The findings of Auwerx's team have been published in the scientific journal Nature. The goal of the research was to work out why certain individuals of the same species can have a far longer life-span than others. "Our lab has for some time been using a complex genetic reference population of mice, which mimic the human population, to study ageing," said Auwerx. The scientists started by examining mice's mitochondria – a cell's version of a power plant – and uncovered a group of three genes that affected the animals' life-span via their speed of functioning. Those whose genes were 50 per cent slower lived some 250 days longer, or about 30 per cent of a mouse's lifetime. "Based on this observation, we switched model, and started validating this experimentally in a worm," said Auwerx. "Knocking down the same proteins, we could see an up to 60 per cent extension of worm life-span," he added. Auwerx underlined that since mitochondria are bacteria living within cells, his team then experimented with antibiotics, which target bacteria. "We could see that treating the worms with the antibiotics also mimicked the genetic effects, and they also lived 60 per cent longer," from 19 days to 30, he explained. Mitochondria transform nutrients into various kinds of protein, and several previous studies have suggested that they may be the motor of ageing. The Swiss team, working with counterparts in the Netherlands and United States, managed to identify the specific gene involved in the process and work out how variations in protein could affect life-span. They worked out that so-called MRPs – for mitochondrial ribosomal proteins – had an inversely proportional impact on longevity. In addition, they found that a lack of MRPs at key moments of an individual's early development caused stress on mitochondria. This has short-term negative impacts such as a fall in fertility, but in the long term appeared to result in a better muscle structure as well as a longer life. The researchers underlined that further studies would be needed to confirm whether antibiotics could be used to rein in ageing in mammals. – AFP/Relaxnews |
| China urbanisation plan hits roadblock over spending fears Posted: 23 May 2013 04:26 AM PDT
Premier Li Keqiang has rejected an urbanisation proposal drafted by the National Development and Reform Commission (NDRC), seeking changes to put more emphasis on economic reform, according to the sources, who are familiar with the matter. Many local authorities have already lobbied to get funding for projects, ringing alarm bells among top leaders in Beijing. State-owned China Development Bank recently pledged to lend 150 billion yuan (RM74.25 billion) to southeastern Fujian province to support its urbanisation and channel 30 billion yuan into urban projects in central Anhui province, according to Chinese media. "The urbanisation plan could be delayed. Top leaders have seen potential risks if the programme cannot be kept on the right path," said an economist at a top think-tank which advises the Cabinet. "The leadership aims to jumpstart reforms, but local governments see this in a different perspective – they view this as the last opportunity to boost investment," said the economist who requested anonymity due to the sensitivity of the issue. China plans to spend some US$6.5 trillion to bring 400 million people to its cities over the next decade as leaders such as Li try to sustain economic growth that slowed to a 13-year low of 7.8 per cent in 2012. Li, the driving force behind urbanisation, has turned more cautious following warnings from leading academics over the risks, said the think-tank sources who are involved in the policy discussions. The NDRC is racing against the clock to amend the long-term plan in a bid to publish it by the end of June. STIMULUS HANGOVER Beijing is still nursing a hangover from its four trillion yuan stimulus package launched in 2008 to counter the global financial crisis, which left local governments under a mountain of debt and sent house prices rocketing. To fund the urbanisation plan, local governments would issue long-term bonds to finance spending on roads, housing and social safety nets, Reuters reported in March, quoting sources with ties to the leadership. But a fiscal overhaul is needed because local governments don't have steady tax revenues to back the issuance of bonds. Under China's tax structure, in place since 1994, the central government gets most receipts while local governments do the spending, forcing them to rely on land sales for survival. To support the process, Beijing needed to overhaul its land and tax codes as well as free up the rigid residency registration, or "hukou", system to give migrant workers access to education, health and other services where they work, experts have said. Li wanted more detail on these sorts of reforms in the plan, the sources said. "The focus of the urbanisation drive should be land and hukou reforms. It's doomed if China continues to rely on local government spending to support urbanisation," said Yi Xianrong, senior economist at the Chinese Academy of Social Sciences (CASS), a leading government think-tank in Beijing. Ratings agency Fitch estimates local government debt at 13 trillion yuan, or a quarter of GDP. Government data puts the number at 10.7 trillion yuan. China's housing inflation accelerated to its fastest pace in April in two years, despite stricter measures by Beijing to calm a frothy real estate market. 'RIDING A TIGER' The government hopes 60 per cent of China's population of almost 1.4 billion will be urban residents by 2020. China's official urbanisation rate is near 53 per cent, but the real level is only around 35 per cent as millions of migrant workers have been artificially included in the urban population, sparking criticism of "fake urbanisation". Some analysts are looking for guidance from a key meeting of the ruling Communist Party, expected in October, that will set the agenda for the next decade. Others are not so sure. "I don't expect any policy breakthroughs this year as government departments still have different views," said Xiang Songzuo, chief economist at the Agricultural Bank of China . "I feel that the top leadership may not have a clear idea on how to proceed with the urbanisation strategy," said Xiang, who has been advising the government on urbanisation issues. Li Yining, the premier's former teacher at Peking University, recently said Chinese banks could be dragged into another spending binge that could spark a financial crisis. But Premier Li is unlikely to backpedal on the urbanisation drive, with his interest in the issue seen as far back as the early 1990s when he wrote a doctoral thesis on the subject. One of his key arguments was to reform the hukou system. "It's like riding a tiger – it's not easy to get off once you're on," said a government economist who declined to be identified. – Reuters |
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